AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Plasma membrane pro and euk12/11/2022 ![]() Occurrence Handle1:CAS:528:DC%2BD28Xht1Sks7s%3DĪrticleTitleRelation between amino acid composition and cellular location of proteins ![]() Occurrence Handle1:CAS:528:DC%2BD3sXhtVSrur%2FMĪrticleTitlePrediction of protein structural class with Rough Sets Occurrence Handle1:CAS:528:DC%2BD3cXjtFSlsbc%3DĪrticleTitleThe SWISS-PROT protein sequence data bank and its supplement TrEMBLĪrticleTitleThe Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology Occurrence Handle1:CAS:528:DC%2BD3sXhtVSru7vKĪrticleTitleGene ontology: tool for the unification of biology The large-scale results will be updated twice a year to include the new entries of eukaryotic proteins and reflect the continuous development of Euk-PLoc.ĪrticleTitleUniProt: the Universal Protein knowledgebase Furthermore, to support the need of people working in the relevant areas, a downloadable file will be provided at the same website to list the results predicted by Euk-PLoc for all eukaryotic protein entries (excluding fragments) in Swiss-Prot database that do not have subcellular location annotations or are annotated as being uncertain. The powerful predictor, named “Euk-PLoc”, is available as a web-server at. The overall success rates thus obtained via the 5-fold and jackknife cross-validation tests were 81.6 and 80.3%, respectively, which were 40–50% higher than those performed by the other existing methods on the same strict dataset. To avoid the homology bias, none of the proteins included has ≥25% sequence identity to any other in a same subcellular location. As a demonstration, a new benchmark dataset was constructed that covers the following 18 localizations: (1) cell wall, (2) centriole, (3) chloroplast, (4) cyanelle, (5) cytoplasm, (6) cytoskeleton, (7) endoplasmic reticulum, (8) extracell, (9) Golgi apparatus, (10) hydrogenosome, (11) lysosome, (12) mitochondria, (13) nucleus, (14) peroxisome, (15) plasma membrane, (16) plastid, (17) spindle pole body, and (18) vacuole. Each of these basic classifiers was engineered by the KNN (K-Nearest Neighbor) principle. Based on such a representation, a novel ensemble hybridization classifier was developed by fusing many basic individual classifiers through a voting system. To cope with the challenge, protein samples are formulated by hybridizing the information derived from the gene ontology database and amphiphilic pseudo amino acid composition. However, predicting subcellular location of eukaryotic proteins is a challenging problem, particularly when unknown query proteins do not have significant homology to proteins of known subcellular locations and when more locations need to be covered. With the avalanche of newly-found protein sequences emerging in the post genomic era, it is highly desirable to develop an automated method for fast and reliably identifying their subcellular locations because knowledge thus obtained can provide key clues for revealing their functions and understanding how they interact with each other in cellular networking. ![]()
0 Comments
Read More
Leave a Reply. |